General Information

  • ID:  hor002471
  • Uniprot ID:  Q7M2Z8
  • Protein name:  TRH-potentiating peptide
  • Gene name:  NA
  • Organism:  Bos taurus (Bovine)
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  SFPWMESDVT
  • Length:  10
  • Propeptide:  SFPWMESDVT
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Potentiates TRH-evoked thyrotropin secretion by antehypophysis
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002471_AF2.pdbhor002471_ESM.pdb

Physical Information

Mass: 135901 Formula: C54H75N11O18S
Absent amino acids: ACGHIKLNQRY Common amino acids: S
pI: 3.55 Basic residues: 0
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -29 Boman Index: -1320
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 29
Instability Index: 5983 Extinction Coefficient cystines: 5500
Absorbance 280nm: 611.11

Literature

  • PubMed ID:  1472021
  • Title:  Isolation and Amino Acid Sequence of the TRH-potentiating Peptide From Bovine Hypothalamus